Mingmu Xiaoyao granules regulate the PI3K/Akt/mTOR signaling pathway to reduce anxiety and depression and reverse retinal abnormalities in rats

Mingmu Xiaoyao granules regulate the PI3K/Akt/mTOR signaling pathway to reduce anxiety and depression and reverse retinal abnormalities in rats

Objective: To investigate the effects of Mingmu Xiaoyao granules (MMXY) on the morphology and function of the retina and the mechanism of PI3K/Akt/mTOR pathway-related proteins in rats with anxiety and depression induced by chronic unpredictable mild stress (CUMS).Methods: Fifty-two male Sprague Daw...

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Bibliographic Details
Main Authors: Qiuyan Ma, Jian Zhou, Ziyi Yang, Yuxin Xue, Xinran Xie, Tiejun Li, Yingxin Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
Mingmu Xiaoyao granules
retinal thickness
retinal blood flow
PI3K/Akt/mTOR pathway
autophagy
depression
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1003614/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1003614/full

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