Trasmembrane chemokines CX3CL1 and CXCL16 drive interplay between neurons, microglia and astrocytes to counteract pMCAO and excitotoxic neuronal death.

Trasmembrane chemokines CX3CL1 and CXCL16 drive interplay between neurons, microglia and astrocytes to counteract pMCAO and excitotoxic neuronal death.

Upon noxious insults, cells of the brain parenchyma activate endogenous self-protective mechanisms to counteract brain damage. Interplay between microglia and astrocytes can be determinant to build a physiological response to noxious stimuli arisen from injury or stress, thus understanding the cross...

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Bibliographic Details
Main Authors: Maria eRosito, Clotilde eLauro, Giuseppina eChece, Alessandra ePorzia, Lucia eMonaco, Fabrizio eMainiero, Myriam eCatalano, Cristina eLimatola, Flavia eTrettel
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Ischemia
Neuroprotection
CX3CL1
CXCL16
CCL2
A3R
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00193/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00193/full

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