Umbilical Cord Mesenchymal Stem Cells Ameliorate Kidney Injury in MRL/Ipr Mice Through the TGF-β1 Pathway

Umbilical Cord Mesenchymal Stem Cells Ameliorate Kidney Injury in MRL/Ipr Mice Through the TGF-β1 Pathway

The therapeutic effects and mechanism of umbilical cord mesenchymal stem cells (UC-MSC) on kidney injury in MRL/Ipr mice were studied. UC-MSC, methylprednisolone (MP), and their combination were used to treat MRL/Ipr mice. The therapeutic effects were evaluated by renal function assessment, and HE,...

Full description

Bibliographic Details
Main Authors: Chunkai Huang, Mingyao Meng, Shuo Li, Shiyuan Liu, Lin Li, Yanjun Su, Hui Gao, Shan He, Yiyi Zhao, Min Zhang, Zongliu Hou, Wenju Wang, Xiaodan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
lupus nephritis
umbilical cord mesenchymal stem cells
podocytes
TGF-β1
p-Smad3
TRAF6
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.876054/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.876054/full

Similar Items