Identification of Novel Cyclooxygenase-1 Selective Inhibitors of Thiadiazole-Based Scaffold as Potent Anti-Inflammatory Agents with Safety Gastric and Cytotoxic Profile

Identification of Novel Cyclooxygenase-1 Selective Inhibitors of Thiadiazole-Based Scaffold as Potent Anti-Inflammatory Agents with Safety Gastric and Cytotoxic Profile

Major obstacles faced by the use of nonsteroidal anti-inflammatory drugs (NSAID) are their gastrointestinal toxicity induced by non-selective inhibition of both cyclooxygenases (COX) 1 and 2 and their cardiotoxicity associated with a certain class of COX-2 selective inhibitors. Recent studies have d...

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Bibliographic Details
Main Authors: Michelyne Haroun, Maria Fesatidou, Anthi Petrou, Christophe Tratrat, Panagiotis Zagaliotis, Antonis Gavalas, Katharigatta N. Venugopala, Hafedh Kochkar, Promise M. Emeka, Nancy S. Younis, Dalia Ahmed Elmaghraby, Mervt M. Almostafa, Muhammad Shahzad Chohan, Ioannis S. Vizirianakis, Aliki Papadimitriou-Tsantarliotou, Athina Geronikaki
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
molecular modeling
thiadiazole
enzyme inhibition
anti-inflammatory
ulcerogenic effect
cyclooxygenase
Online Access:https://www.mdpi.com/1420-3049/28/8/3416

Internet

https://www.mdpi.com/1420-3049/28/8/3416

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