Phosphoglycerate kinase 1 acts as a cargo adaptor to promote EGFR transport to the lysosome

Phosphoglycerate kinase 1 acts as a cargo adaptor to promote EGFR transport to the lysosome

Abstract The epidermal growth factor receptor (EGFR) plays important roles in multiple cellular events, including growth, differentiation, and motility. A major mechanism of downregulating EGFR function involves its endocytic transport to the lysosome. Sorting of proteins into intracellular pathways...

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Bibliographic Details
Main Authors: Shao-Ling Chu, Jia-Rong Huang, Yu-Tzu Chang, Shu-Yun Yao, Jia-Shu Yang, Victor W. Hsu, Jia-Wei Hsu
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45443-4

Internet

https://doi.org/10.1038/s41467-024-45443-4

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