Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer’s Disease Potential

Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer’s Disease Potential

Marine alkaloids belonging to the lamellarins family, which incorporate a 5,6-dihydro-1-phenylpyrrolo[2,1-<i>a</i>]isoquinoline (DHPPIQ) moiety, possess various biological activities, spanning from antiviral and antibiotic activities to cytotoxicity against tumor cells and the reversal o...

Full description

Bibliographic Details
Main Authors:	Alisa A. Nevskaya, Lada V. Anikina, Rosa Purgatorio, Marco Catto, Orazio Nicolotti, Modesto de Candia, Leonardo Pisani, Tatiana N. Borisova, Almira R. Miftyakhova, Aleksey V. Varlamov, Elena Yu. Nevskaya, Roman S. Borisov, Leonid G. Voskressensky, Cosimo D. Altomare
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Series:	Molecules
Subjects:	acetylcholinesterase inhibitors β-amyloid aggregation anti-Alzheimer’s disease agents cytotoxicity pyrrolo[2,1-<i>a</i>]isoquinolines
Online Access:	https://www.mdpi.com/1420-3049/26/2/359

Similar Items

Nature-Inspired 1-Phenylpyrrolo[2,1-<i>a</i>]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance
by: Alisa A. Nevskaya, et al.
Published: (2024-04-01)

An Overview on the Synthesis of Lamellarins and Related Compounds with Biological Interest
by: Vasiliki-Panagiota M. Mitsiou, et al.
Published: (2024-08-01)

Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity
by: Rosa Purgatorio, et al.
Published: (2018-06-01)

Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases
by: Rosa Purgatorio, et al.
Published: (2022-07-01)

Synthesis of Unexpected Dimethyl 2-(4-Chlorophenyl)-2,3-dihydropyrrolo[2,1-<em>a</em>]isoquinoline-1,3-dicarboxylate via Hydrolysis/Cycloaddition/Elimination Cascades: Single Crystal X-ray and Chemical Structure Insights
by: Mezna Saleh Altowyan, et al.
Published: (2021-12-01)

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease
by: Rosa Purgatorio, et al.
Published: (2020-12-01)

A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics
by: Rosa Purgatorio, et al.
Published: (2024-01-01)

Isolation of microorganisms capable of degrading isoquinoline under aerobic conditions /
by: 304503 Aislabie, Jackie, et al.

A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B
by: Ahmad K. Haidar, et al.
Published: (2022-01-01)

Synthesis of New β-enaminones of Isoquinolines with 5,5-dimethyl-cyclohexanedione
by: Stoyanka Nikolova, et al.
Published: (2008-03-01)

Repositioning of Dantrolene as a Multitarget Agent for Neurodegenerative Diseases
by: Isabella Bolognino, et al.
Published: (2019-08-01)

Synthesis of the New Ring System Bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and Its Deaza Analogue
by: Barbara Parrino, et al.
Published: (2014-08-01)

Anticancer Properties of Lamellarins
by: Christian Bailly
Published: (2015-02-01)

Can Isoquinoline Alkaloids Affect Platelet Aggregation in Whole Human Blood?
by: Mst Shamima Parvin, et al.
Published: (2022-07-01)

Synthesis and Anti-HIV Activity of a Novel Series of Isoquinoline-Based CXCR4 Antagonists
by: Mastaneh Safarnejad Shad, et al.
Published: (2021-10-01)

Facile Synthesis of 3-Substituted Thiazolo[2,3-α]tetrahydroisoquinolines
by: Sheng-Han Huang, et al.
Published: (2021-10-01)

Recent Advances in the Synthesis of Isoquinoline-Fused Benzimidazoles
by: Dylan J. Twardy, et al.
Published: (2022-03-01)

Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity
by: Alexander A. Titov, et al.
Published: (2022-09-01)

Investigation on Novel <i>E/Z</i> 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity
by: Marco Paolino, et al.
Published: (2023-08-01)

(Iso)quinoline amides derived from corosolic acid exhibit high cytotoxicity, and the potential for overcoming drug resistance in human cancer cells
by: Niels V. Heise, et al.
Published: (2024-12-01)

Protective effect of Macleaya cordata isoquinoline alkaloids on lipopolysaccharide-induced liver injury in broilers
by: Jiaxin Chen, et al.
Published: (2024-01-01)

Research Progress on Neuroprotective Effects of Isoquinoline Alkaloids
by: Jinhua Li, et al.
Published: (2023-06-01)

Total Syntheses of Telisatin A, Telisatin B and Lettowianthine
Published: (2009-02-01)

Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors
by: Amany Belal, et al.
Published: (2022-12-01)

Synthetic Approaches to the Lamellarins—A Comprehensive Review
by: Dennis Imbri, et al.
Published: (2014-12-01)

Anticancer Alkaloid Lamellarins Inhibit Protein Kinases
by: Laurent Meijer, et al.
Published: (2008-10-01)

TO THE QUESTION OF SYNTHESIS AND STANDARDIZATION OF PHARMACOLOGICALLY ACTIVE PYRIDINE AND PYRROLE DERIVATIVES
by: S. Comesse, et al.
Published: (2019-01-01)

Stereochemical Behavior of Pyrrolo-Pyrazole Peptidomimetics Promoting Phase-Selective Supramolecular Organogels
by: Enrica Chiesa, et al.
Published: (2024-04-01)

Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives
by: Lacramioara Popovici, et al.
Published: (2019-01-01)

Mono- and Diamination of 4,6-Dichloropyrimidine, 2,6-Dichloropyrazine and 1,3-Dichloroisoquinoline with Adamantane-Containing Amines
by: Alisa D. Kharlamova, et al.
Published: (2021-03-01)

Phellodendronoside A Exerts Anticancer Effects Depending on Inducing Apoptosis Through ROS/Nrf2/Notch Pathway and Modulating Metabolite Profiles in Hepatocellular Carcinoma
by: Si Y, et al.
Published: (2023-06-01)

Design, synthesis and biological evaluation of spiroisoquinoline-pyrimidine derivatives as anticancer agents against MCF-7 cancer cell lines
by: Shruti Gupta, et al.
Published: (2022-01-01)

Amides, Isoquinoline Alkaloids and Dipeptides from the Aerial Parts of Piper mullesua
by: Meng-Yuan Xia, et al.
Published: (2018-08-01)

7-Acetyl-8-(4-chlorophenyl)-3-ethylsulfanyl-6-hydroxy-1,6-dimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
by: Joel T. Mague, et al.
Published: (2017-03-01)

Total Synthesis and Antimicrobial Activity of (Ã‚Â±)-Laurelliptinhexadecan-1-one and (Ã‚Â±)-Laurelliptinoctadecan-1-one
by: Surachai Nimgirawath, et al.
Published: (2008-11-01)

Concise synthesis of pyrrolo[2,3-d]pyrimidine derivatives via the Cu-catalyzed coupling reaction
by: Leilei Wang, et al.
Published: (2017-01-01)

The Role of Hydrogen Bond Interactions in Crystal Formation of Pyrrolo-Azines Alcohols
by: Marcel Mirel Popa, et al.
Published: (2025-01-01)

Transcriptome analysis reveals cadmium exposure enhanced the isoquinoline alkaloid biosynthesis and disease resistance in Coptis chinensis
by: Xin Li, et al.
Published: (2024-02-01)

Insecticidal Activity of Extracts, Fractions, and Pure Molecules of <i>Cissampelos pareira</i> Linnaeus against Aphid, <i>Aphis craccivora</i> Koch
by: Surekha Kumari, et al.
Published: (2022-01-01)

Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of <i>Chelidonium majus</i> Isoquinoline Alkaloids
by: Maciej Strzemski, et al.
Published: (2022-04-01)