Selective CB<sub>2</sub> Receptor Agonist, HU-308, Reduces Systemic Inflammation in Endotoxin Model of Pneumonia-Induced Acute Lung Injury

Selective CB<sub>2</sub> Receptor Agonist, HU-308, Reduces Systemic Inflammation in Endotoxin Model of Pneumonia-Induced Acute Lung Injury

Acute respiratory distress syndrome (ARDS) and sepsis are risk factors contributing to mortality in patients with pneumonia. In ARDS, also termed acute lung injury (ALI), pulmonary immune responses lead to excessive pro-inflammatory cytokine release and aberrant alveolar neutrophil infiltration. Sys...

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Bibliographic Details
Main Authors: Stefan Hall, Sufyan Faridi, Purvi Trivedi, Saki Sultana, Bithika Ray, Tanya Myers, Irene Euodia, David Vlatten, Mathieu Castonguay, Juan Zhou, Melanie Kelly, Christian Lehmann
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
acute lung injury
ARDS
inflammation
cytokines
cannabinoid type II receptor (CB<sub>2</sub>)
intravital microscopy
Online Access:https://www.mdpi.com/1422-0067/23/24/15857

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https://www.mdpi.com/1422-0067/23/24/15857

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