Inhibition of MurA Enzyme from <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> by Diterpenes from <i>Lepechinia meyenii</i> and Their Synthetic Analogs

Inhibition of MurA Enzyme from <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> by Diterpenes from <i>Lepechinia meyenii</i> and Their Synthetic Analogs

Enzymes MurA and MurF, involved in bacterial cell wall synthesis, have been validated as targets for the discovery of novel antibiotics. A panel of plant-origin antibacterial diterpenes and synthetic analogs derived therefrom were investigated for their inhibitory properties on these enzymes from &l...

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Bibliographic Details
Main Authors: Macarena Funes Chabán, Martina Hrast, Rok Frlan, Dafni G. Graikioti, Constantinos M. Athanassopoulos, María Cecilia Carpinella
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antibiotics
Subjects:
dehydroabietane derivatives
diterpenes
MurA and MurF inhibitors
<i>Staphylococcus aureus</i> MurA
<i>Escherichia coli</i> MurA
Online Access:https://www.mdpi.com/2079-6382/10/12/1535

Internet

https://www.mdpi.com/2079-6382/10/12/1535

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