Investigating G-quadruplex structures in RPGR gene: Implications for understanding X-linked retinal degeneration

Investigating G-quadruplex structures in RPGR gene: Implications for understanding X-linked retinal degeneration

Aims: This pilot study investigates the potential pathogenic role of G-quadruplex (G4) structures in RPGR-associated retinal degeneration, starting from a case of suspected X-linked form affected family. We hypothesize that the stabilization of these structures might alter DNA replication and transc...

Full description

Bibliographic Details
Main Authors: Luigi Donato, Concetta Scimone, Simona Alibrandi, Domenico Mordà, Ivan Anchesi, Sergio Zaccaria Scalinci, Carmela Rinaldi, Rosalia D'Angelo, Antonina Sidoti
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Heliyon
Subjects:
G-quadruplex
RPGR
WGA
Pyridostatin
DNA-Polymerase
RNA-Polymerase
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024058596

Internet

http://www.sciencedirect.com/science/article/pii/S2405844024058596

Similar Items