9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity.

9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity.

The induction of a broadly neutralizing antibody (BNAb) response against HIV-1 would be a desirable feature of a protective vaccine. Vaccine strategies thus far have failed to elicit broadly neutralizing antibody responses; however a minority of HIV-infected patients do develop circulating BNAbs, fr...

Full description

Bibliographic Details
Main Authors: James J Kobie, Danielle C Alcena, Bo Zheng, Peter Bryk, Jonelle L Mattiacio, Matthew Brewer, Celia Labranche, Faith M Young, Stephen Dewhurst, David C Montefiori, Alexander F Rosenberg, Changyong Feng, Xia Jin, Michael C Keefer, Ignacio Sanz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3329433?pdf=render

Internet

http://europepmc.org/articles/PMC3329433?pdf=render

Similar Items