Sulforaphane, a naturally occurring isothiocyanate, exhibits anti-inflammatory effects by targeting GSK3β/Nrf-2 and NF-κB pathways in T cells

Sulforaphane, a naturally occurring isothiocyanate, exhibits anti-inflammatory effects by targeting GSK3β/Nrf-2 and NF-κB pathways in T cells

A potent Nrf-2 activator sulforaphane (SF), which is currently under clinical trials for cancer therapy, was employed to elucidate the role of Keap1/Nrf-2/ARE signalling pathway in T-cell responses. SF suppressed mitogen induced T-cell and B-cell proliferation. It also inhibited mitogen induced upre...

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Bibliographic Details
Main Authors: Rahul Checker, Lokesh Gambhir, Maikho Thoh, Deepak Sharma, Santosh K. Sandur
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Journal of Functional Foods
Subjects:
Cytokines
GSH/GSSG
ROS
GSK3β
Homeostatic proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615004156

Internet

http://www.sciencedirect.com/science/article/pii/S1756464615004156

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