Transient abnormal myelopoiesis with extramedullary involvement in a down syndrome preemie leading to an unresponsive course despite chemotherapy

Transient abnormal myelopoiesis with extramedullary involvement in a down syndrome preemie leading to an unresponsive course despite chemotherapy

Introduction: Transient abnormal myelopoiesis (TAM) is a transient, clonal myeloproliferative disorder unique to Down Syndrome (DS) babies. It is characterized by increased peripheral blasts and presence of GATA1 mutation. The clinical spectrum ranges from jaundice and hepatosplenomegaly to multi-or...

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Bibliographic Details
Main Authors: Saroja Devi Geetha, Ram Singh, Meira Shaham, Ninette Cohen, Kristin Sticco
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Leukemia Research Reports
Subjects:
Down syndrome
Transient abnormal myelopoiesis
Transient leukemia
Transient myeloproliferative disorder
Leukemia in Down syndrome
Megakaryoblastic leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048923000213

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http://www.sciencedirect.com/science/article/pii/S2213048923000213

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