Aldo-keto reductase family 1 member A1 (AKR1A1) exerts a protective function in alcohol-associated liver disease by reducing 4-HNE accumulation and p53 activation

Aldo-keto reductase family 1 member A1 (AKR1A1) exerts a protective function in alcohol-associated liver disease by reducing 4-HNE accumulation and p53 activation

Abstract Background The development of alcohol-associated liver disease (ALD) is influenced by the amount and duration of alcohol consumption. The resulting liver damage can range from reversible stages, such as steatosis, steatohepatitis and alcoholic fibrosis, to the advanced and irreversible stag...

Full description

Bibliographic Details
Main Authors: Ying-Wei Lan, Wan-Ru Chen, Gary Ro-Lin Chang, Ying-Cheng Chen, Kowit-Yu Chong, Kai-Cheng Chuang, Yung-Tsung Kao, Ming-Shan Chen, Chuan-Mu Chen
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cell & Bioscience
Subjects:
Alcohol-associated liver disease (ALD)
Aldo-keto reductase family 1 member A1 (AKR1A1)
4-HNE
p53
Lipid accumulation
Liver fibrosis
Online Access:https://doi.org/10.1186/s13578-024-01200-0

Internet

https://doi.org/10.1186/s13578-024-01200-0

Similar Items