Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer

Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer

Abstract The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1 (PD-1)/ programmed cell death-ligand 1 (PD-L1) are two most representative immune checkpoint pathways, which negatively regulate T cell immune function during different phases of T-cell activation. Inhibitors...

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Bibliographic Details
Main Authors: Hao Zhang, Ziyu Dai, Wantao Wu, Zeyu Wang, Nan Zhang, Liyang Zhang, Wen-Jing Zeng, Zhixiong Liu, Quan Cheng
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
PD-L1
CTLA-4
Cancer immunotherapy
Regulatory mechanism
Drug intervention
Online Access:https://doi.org/10.1186/s13046-021-01987-7

Internet

https://doi.org/10.1186/s13046-021-01987-7

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