Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain

Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain

ABSTRACT Zika virus (ZIKV) infection during early pregnancy can cause microcephaly and associated defects at birth, but whether it can induce neurologic sequelae that appear later in life remains unclear. Using a model of the developing brain based on embryonic stem cell-derived brain organoids, we...

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Bibliographic Details
Main Authors: Sylvie Janssens, Michael Schotsaert, Rahul Karnik, Vinod Balasubramaniam, Marion Dejosez, Alexander Meissner, Adolfo García-Sastre, Thomas P. Zwaka
Format: Article
Language:English
Published: American Society for Microbiology 2018-02-01
Series:mSystems
Subjects:
DNA methylation
Zika virus
astrocytes
brain disorders
microcephaly
neurons
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00219-17

Internet

https://journals.asm.org/doi/10.1128/mSystems.00219-17

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