Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1.

Bak is a critical executor of apoptosis belonging to the Bcl-2 protein family. Bak contains a hydrophobic groove where the BH3 domain of proapoptotic Bcl-2 family members can be accommodated, which initiates its activation. Once activated, Bak undergoes a conformational change to oligomerize, which...

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Bibliographic Details
Main Authors: Dahwan Lim, So-Hui Choe, Sein Jin, Seulgi Lee, Younjin Kim, Ho-Chul Shin, Joon Sig Choi, Doo-Byoung Oh, Seung Jun Kim, Jinho Seo, Bonsu Ku
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002156