Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer’s Disease: A PET (THK5351, PiB) and Resting fMRI Study

Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer’s Disease: A PET (THK5351, PiB) and Resting fMRI Study

Background: Imaging studies in Alzheimer’s disease (AD) have yet to answer the underlying questions concerning the relationship among tau retention, neuroinflammation, network disruption and cognitive decline. We compared the spatial retention patterns of 18F-THK5351 and resting state network (RSN)...

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Main Authors: Takamasa Yokoi, Hirohisa Watanabe, Hiroshi Yamaguchi, Epifanio Bagarinao, Michihito Masuda, Kazunori Imai, Aya Ogura, Reiko Ohdake, Kazuya Kawabata, Kazuhiro Hara, Yuichi Riku, Shinsuke Ishigaki, Masahisa Katsuno, Shinichi Miyao, Katsuhiko Kato, Shinji Naganawa, Ryuichi Harada, Nobuyuki Okamura, Kazuhiko Yanai, Mari Yoshida, Gen Sobue
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
18F-THK5351
11C-PiB
positron emission tomography (PET)
resting state network
MRI
MAO-B
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00304/full

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https://www.frontiersin.org/article/10.3389/fnagi.2018.00304/full

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