The Molecular Mechanisms of Resistance to IDH Inhibitors in Acute Myeloid Leukemia

The Molecular Mechanisms of Resistance to IDH Inhibitors in Acute Myeloid Leukemia

Gain-of-function mutations of isocitrate dehydrogenases 1/2 (IDH1/2) play crucial roles in the development and progression of acute myeloid leukemia (AML), which provide promising therapeutic targets. Two small molecular inhibitors, ivosidenib and enasidenib have been approved for the treatment of I...

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Main Authors: Xiaomei Zhuang, Han Zhong Pei, Tianwen Li, Junbin Huang, Yao Guo, Yuming Zhao, Ming Yang, Dengyang Zhang, Zhiguang Chang, Qi Zhang, Liuting Yu, Chunxiao He, Liqing Zhang, Yihang Pan, Chun Chen, Yun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
cancer metabolism
IDH1
IDH2
acute myeloid leukemia
drug resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.931462/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.931462/full

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