Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure
Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever. This study investigated the effects of temperature and compaction pressure on tablet disi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/12/2725 |
| _version_ | 1827637287161167872 |
|---|---|
| author | Audrey Yi Zheng Paul Wan Sia Heng Lai Wah Chan |
| author_facet | Audrey Yi Zheng Paul Wan Sia Heng Lai Wah Chan |
| author_sort | Audrey Yi Zheng |
| collection | DOAJ |
| description | Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever. This study investigated the effects of temperature and compaction pressure on tablet disintegratability to gain deeper insights into superdisintegrant sensitivity and function. Tablets with either sodium starch glycolate or crospovidone as disintegrant were prepared at various compaction pressures and subjected to the disintegration test using different medium temperatures. Preheating of tablets was also employed to establish instant temperature equilibrium between the tablet and the disintegration medium. Liquid penetration and disintegration were faster as the medium temperature increased or compaction pressure decreased. Swelling or strain recovery disintegrants exhibited similar sensitivity to variations in the medium temperature. Preheating of the tablets resulted in slower disintegration, but this effect was reversible upon cooling, hence the slower disintegration was unlikely to be attributed to changes in the disintegrant physical state. The temperature difference between the tablet and the disintegration medium likely affected the rate of fluid flow into tablets and influenced disintegration. Understanding disintegrant temperature sensitivity would help to avoid unacceptable fluctuations in disintegration due to temperature variations. The temperature difference effect could also be harnessed to boost disintegrant performance. |
| first_indexed | 2024-03-09T15:58:04Z |
| format | Article |
| id | doaj.art-18be8846ff074ae794b7b6c12378453d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:04Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-18be8846ff074ae794b7b6c12378453d2023-11-24T17:20:59ZengMDPI AGPharmaceutics1999-49232022-12-011412272510.3390/pharmaceutics14122725Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction PressureAudrey Yi Zheng0Paul Wan Sia Heng1Lai Wah Chan2GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, SingaporeGEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, SingaporeGEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, SingaporeTablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever. This study investigated the effects of temperature and compaction pressure on tablet disintegratability to gain deeper insights into superdisintegrant sensitivity and function. Tablets with either sodium starch glycolate or crospovidone as disintegrant were prepared at various compaction pressures and subjected to the disintegration test using different medium temperatures. Preheating of tablets was also employed to establish instant temperature equilibrium between the tablet and the disintegration medium. Liquid penetration and disintegration were faster as the medium temperature increased or compaction pressure decreased. Swelling or strain recovery disintegrants exhibited similar sensitivity to variations in the medium temperature. Preheating of the tablets resulted in slower disintegration, but this effect was reversible upon cooling, hence the slower disintegration was unlikely to be attributed to changes in the disintegrant physical state. The temperature difference between the tablet and the disintegration medium likely affected the rate of fluid flow into tablets and influenced disintegration. Understanding disintegrant temperature sensitivity would help to avoid unacceptable fluctuations in disintegration due to temperature variations. The temperature difference effect could also be harnessed to boost disintegrant performance.https://www.mdpi.com/1999-4923/14/12/2725disintegrationtemperaturesuperdisintegrantswellingstrain recoverytablet |
| spellingShingle | Audrey Yi Zheng Paul Wan Sia Heng Lai Wah Chan Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure Pharmaceutics disintegration temperature superdisintegrant swelling strain recovery tablet |
| title | Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure |
| title_full | Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure |
| title_fullStr | Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure |
| title_full_unstemmed | Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure |
| title_short | Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure |
| title_sort | tablet disintegratability sensitivity of superdisintegrants to temperature and compaction pressure |
| topic | disintegration temperature superdisintegrant swelling strain recovery tablet |
| url | https://www.mdpi.com/1999-4923/14/12/2725 |
| work_keys_str_mv | AT audreyyizheng tabletdisintegratabilitysensitivityofsuperdisintegrantstotemperatureandcompactionpressure AT paulwansiaheng tabletdisintegratabilitysensitivityofsuperdisintegrantstotemperatureandcompactionpressure AT laiwahchan tabletdisintegratabilitysensitivityofsuperdisintegrantstotemperatureandcompactionpressure |