Development of a fully human anti‐GITR antibody with potent antitumor activity using H2L2 mice

Development of a fully human anti‐GITR antibody with potent antitumor activity using H2L2 mice

Glucocorticoid‐induced TNF receptor‐related (GITR) can act as a co‐stimulatory receptor, representing a potential target for safely enhancing immunotherapy efficacy. GITR is triggered by a GITR ligand or an agonist antibody and activates CD8+ and CD4+ effector T cells, reducing tumor‐infiltrating Tr...

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Bibliographic Details
Main Authors: Qiuli Tong, Hu Liu, Qianqian Qi, Chaohui Dai, Teddy Yang, Feng Qian
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:FEBS Open Bio
Subjects:
engineering modification
fully human antibody
GITR
H2L2 mice
immunization strategies
T cell
Online Access:https://doi.org/10.1002/2211-5463.13451

Internet

https://doi.org/10.1002/2211-5463.13451

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