Angiopoietin2-mediated caveolin1 phosphorylation regulating transcytosis of renal tubular epithelial cell contributes to the occurrence of albuminuria under high glucose exposure

Angiopoietin2-mediated caveolin1 phosphorylation regulating transcytosis of renal tubular epithelial cell contributes to the occurrence of albuminuria under high glucose exposure

Abstract Background Microlbuminuria is the earliest clinical evidence of diabetic kidney disease (DKD) and contributes to the induction and/or progression of DKD. Previous studies have shown that increased expression of angiopoietin2 (ANGPT2) is correlated with an increase in albuminuria. However, t...

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Bibliographic Details
Main Authors: Jing Liu, Junxia Yao, Yi Zhao, Jinxuan Su, Jiajia Ye, Yumei Wang
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Translational Medicine
Subjects:
Diabetic kidney disease
Renal tubular epithelial cells
Transcytosis
Angiopoietin2
Caveolin1
Online Access:https://doi.org/10.1186/s12967-022-03388-6

Internet

https://doi.org/10.1186/s12967-022-03388-6

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