Microbiota-derived 3-phenylpropionic acid promotes myotube hypertrophy by Foxo3/NAD+ signaling pathway

Microbiota-derived 3-phenylpropionic acid promotes myotube hypertrophy by Foxo3/NAD+ signaling pathway

Abstract Background Gut microbiota and their metabolites play a regulatory role in skeletal muscle growth and development, which be known as gut-muscle axis. 3-phenylpropionic acid (3-PPA), a metabolite produced by colonic microorganisms from phenylalanine in the gut, presents in large quantities in...

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Bibliographic Details
Main Authors: Penglin Li, Xiaohua Feng, Zewei Ma, Yexian Yuan, Hongfeng Jiang, Guli Xu, Yunlong Zhu, Xue Yang, Yujun Wang, Canjun Zhu, Songbo Wang, Ping Gao, Qingyan Jiang, Gang Shu
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Cell & Bioscience
Subjects:
3-Phenylpropionic acid
Gut microbiota metabolites
Muscle hypertrophy
NAD+
Acetylation
Online Access:https://doi.org/10.1186/s13578-024-01244-2

Internet

https://doi.org/10.1186/s13578-024-01244-2

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