Amelioration of behavioral abnormalities in BH(4)-deficient mice by dietary supplementation of tyrosine.

This study reports an amelioration of abnormal motor behaviors in tetrahydrobiopterin (BH4)-deficient Spr (-/-) mice by the dietary supplementation of tyrosine. Since BH4 is an essential cofactor for the conversion of phenylalanine into tyrosine as well as the synthesis of dopamine neurotransmitter...

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Bibliographic Details
Main Authors: Sang Su Kwak, Mikyoung Jeong, Ji Hye Choi, Daesoo Kim, Hyesun Min, Yoosik Yoon, Onyou Hwang, Gary G Meadows, Cheol O Joe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3618182?pdf=render