Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli

Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli

Abstract Background Chloroethylnitrosourea (CENU) derivatives, such as nimustine (ACNU) and carmustine (BCNU), are employed in brain tumor chemotherapy due to their ability to cross the blood-brain barrier. They are thought to suppress tumor development through DNA chloroethylation, followed by the...

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Bibliographic Details
Main Authors: Yoko Yamada, Shinji Watanabe, Keinosuke Okamoto, Sakae Arimoto, Eizo Takahashi, Kazuo Negishi, Tomoe Negishi
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Genes and Environment
Subjects:
Chloroethylnitrosourea
Nimustine (ACNU)
Carmustine (BCNU)
DNA repair
Recombination
Interstrand cross-link (ICL)
Online Access:http://link.springer.com/article/10.1186/s41021-019-0123-x

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http://link.springer.com/article/10.1186/s41021-019-0123-x

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