Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice

Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice

ADPKD has few therapeutic options. Tolvaptan slows disease but has side effects limiting its tolerability. Bempedoic acid (BA), an ATP citrate-lyase (ACLY) inhibitor FDA-approved for hypercholesterolemia, catalyzes a key step in fatty acid/sterol synthesis important for cell proliferation. BA is act...

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Bibliographic Details
Main Authors: Kenneth R. Hallows, Hui Li, Biagio Saitta, Saman Sepehr, Polly Huang, Jessica Pham, Jonathan Wang, Valeria Mancino, Eun Ji Chung, Stephen L. Pinkosky, Núria M. Pastor-Soler
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
ACLY
AMPK
ADPKD
metabolism
bempedoic acid
ETC-1002
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1001941/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1001941/full

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