Intestinal organoid modeling: bridging the gap from experimental model to clinical translation

Intestinal organoid modeling: bridging the gap from experimental model to clinical translation

The 3D culture of intestinal organoids entails embedding isolated intestinal crypts and bone marrow mesenchymal stem cells within a growth factor-enriched matrix gel. This process leads to the formation of hollow microspheres with structures resembling intestinal epithelial cells, which are referred...

Full description

Bibliographic Details
Main Authors:	Taotao Liu, Xiaoqi Li, Hao Li, Jingjing Qin, Hui Xu, Jun Wen, Yaqin He, Cao Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Series:	Frontiers in Oncology
Subjects:	intestinal organoids intestinal tumor organoids 3D culture culture environment precision medicine
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1334631/full

Similar Items

Generation of Differentiating and Long-Living Intestinal Organoids Reflecting the Cellular Diversity of Canine Intestine
by: Nina Kramer, et al.
Published: (2020-03-01)

Clinical applications and optimization of patient-derived organoids in intestinal diseases
by: Tae Il Kim
Published: (2022-08-01)

Human Intestinal Organoids: Promise and Challenge
by: Jasin Taelman, et al.
Published: (2022-03-01)

Highly Efficient Methods to Culture Mouse Cholangiocytes and Small Intestine Organoids
by: Wenyi Chen, et al.
Published: (2022-05-01)

Human Organoids for Predictive Toxicology Research and Drug Development
by: Toshikatsu Matsui, et al.
Published: (2021-11-01)

Challenges in validation of combination treatment strategies for CRC using patient-derived organoids
by: Valentin Benboubker, et al.
Published: (2024-09-01)

Disease modeling in organoid cultures: a new tool for studying viruses
by: Jaewon Cho, et al.
Published: (2022-07-01)

Lgr5+ intestinal stem cell sorting and organoid culture
by: Ruixue Liu, et al.
Published: (2019-06-01)

A 3D co-culture intestinal organoid system for exploring glucose metabolism
by: Jianping Nie, et al.
Published: (2023-01-01)

Intestinal Organoids—Current and Future Applications
by: Andre M. C. Meneses, et al.
Published: (2016-10-01)

Application Research Progress of Intestinal Organoids in Nutrient Absorption
by: Yaxuan PENG, et al.
Published: (2022-12-01)

A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids
by: Yu Takahashi, et al.
Published: (2018-01-01)

Wuzhishan miniature pig-derived intestinal 2D monolayer organoids to investigate the enteric coronavirus infection
by: Yuanyuan Liu, et al.
Published: (2024-09-01)

Apical-out intestinal organoids as an alternative model for evaluating deoxynivalenol toxicity and Lactobacillus detoxification in bovine
by: Min Gook Lee, et al.
Published: (2024-12-01)

Creating a More Perfect Union: Modeling Intestinal Bacteria-Epithelial Interactions Using OrganoidsSummary
by: Xiao Han, et al.
Published: (2021-01-01)

Evaluation of 3D Human Intestinal Organoids as a Platform for EV-A71 Antiviral Drug Discovery
by: Fatma Masmoudi, et al.
Published: (2023-04-01)

Effects of Various Marine Toxins on the Mouse Intestine Organoid Model
by: Nengzhuang Wang, et al.
Published: (2022-11-01)

Development of Three-Dimensional Human Intestinal Organoids as a Physiologically Relevant Model for Characterizing the Viral Replication Kinetics and Antiviral Susceptibility of Enteroviruses
by: Jessica Oi-Ling Tsang, et al.
Published: (2021-01-01)

Generation of 3D human gastrointestinal organoids: principle and applications
by: Mengxian Zhang, et al.
Published: (2020-06-01)

Preclinical translational research and application of tumor organoids
by: XIA Yujia, YANG Zhenli, LIU Yuqin
Published: (2024-09-01)

Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids
by: Stacy R. Finkbeiner, et al.
Published: (2015-11-01)

Deliod a lightweight detection model for intestinal organoids based on deep learning
by: Yu Sun, et al.
Published: (2025-02-01)

Intestinal and optic-cup organoids as tools for unveiling mechanics of self-organizing morphogenesis
by: Sristilekha Nath, et al.
Published: (2023-01-01)

Tellu – an object-detector algorithm for automatic classification of intestinal organoids
by: Eva Domènech-Moreno, et al.
Published: (2023-03-01)

Organoid and Enteroid Modeling of Salmonella Infection
by: Yuebang Yin, et al.
Published: (2018-04-01)

PTPRK, an EGFR Phosphatase, Is Decreased in CeD Biopsies and Intestinal Organoids
by: Merlin Nanayakkara, et al.
Published: (2022-12-01)

Prostaglandin E2 supports growth of chicken embryo intestinal organoids in Matrigel matrix
by: Malgorzata Pierzchalska, et al.
Published: (2012-05-01)

Congruence of Transcription Programs in Adult Stem Cell-Derived Jejunum Organoids and Original Tissue During Long-Term Culture
by: Bart van der Hee, et al.
Published: (2020-07-01)

Corrigendum: Organoid and Enteroid Modeling of Salmonella Infection
by: Yuebang Yin, et al.
Published: (2018-07-01)

Methionine deficiency and its hydroxy analogue influence chicken intestinal 3-dimensional organoid development
by: Youli Wang, et al.
Published: (2022-03-01)

The application of intestinal organoids and their co-culture systems in the study of gastrointestinal diseases
by: Panida Sittipo, et al.
Published: (2022-01-01)

Murine colon organoids as a novel model to study Trypanosoma cruzi infection and interactions with the intestinal epithelium
by: Hellen Daghero, et al.
Published: (2023-03-01)

Microfluidic Device to Manipulate 3D Human Epithelial Cell-Derived Intestinal Organoids
by: Miki Matsumoto, et al.
Published: (2022-11-01)

High-fat diet enhances cell proliferation and compromises intestinal permeability in a translational canine intestinal organoid model
by: Itsuma Nagao, et al.
Published: (2024-04-01)

Advancing Intestinal Organoid Technology Toward Regenerative Medicine
by: Tetsuya Nakamura, et al.
Published: (2018-01-01)

Liver organoid culture methods
by: Yiqing Hu, et al.
Published: (2023-11-01)

Long-term organoid culture of a small intestinal neuroendocrine tumor
by: Sabrina D’Agosto, et al.
Published: (2023-04-01)

The Lumen of Human Intestinal Organoids Poses Greater Stress to Bacteria Compared to the Germ-Free Mouse Intestine: <named-content content-type="genus-species">Escherichia coli</named-content> Deficient in RpoS as a Colonization Probe
by: Madeline R. Barron, et al.
Published: (2020-12-01)

Put Some Guts into It: Intestinal Organoid Models to Study Viral Infection
by: Inés García-Rodríguez, et al.
Published: (2020-11-01)

Current applications of intestinal organoids: a review
by: Tao Xiang, et al.
Published: (2024-05-01)