Determination of BRCAness Phenotype in Breast Tumors for the Appointment of Neoadjuvant Chemotherapy Based on Platinum and Taxanes

Determination of BRCAness Phenotype in Breast Tumors for the Appointment of Neoadjuvant Chemotherapy Based on Platinum and Taxanes

The concept of BRCAness was developed because of similarities between sporadic and hereditary breast cancer. BRCAness defines the pathogenesis and treatment sensitivity of many types of cancer, as well as the presence of a defect in the homologous recombination repair of tumor cells simulating the l...

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Bibliographic Details
Main Authors: Matvey Mihajlovich Tsyganov, Marina K. Ibragimova, Evgeniy Y. Garbukov, Olga D. Bragina, Ariana A. Karchevskaya, Evgeny A. Usynin, Nikolai V. Litvyakov
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
BRCAness
homologous recombination
homologous recombination deficiency
breast cancer
gene expression
microarray analysis
Online Access:https://www.mdpi.com/1422-0067/24/1/207

Internet

https://www.mdpi.com/1422-0067/24/1/207

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