Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group

Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group

Histone deacetylase 6 (HDAC6) is an established drug target for cancer treatment. Inhibitors of HDAC6 based on a hydroxamic acid zinc binding group (ZBG) are often associated with undesirable side effects. Herein, we describe the identification of HDAC6 inhibitors based on a completely new 3-hydroxy...

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Bibliographic Details
Main Authors: Pasquale Linciano, Luca Pinzi, Silvia Belluti, Ugo Chianese, Rosaria Benedetti, Davide Moi, Lucia Altucci, Silvia Franchini, Carol Imbriano, Claudia Sorbi, Giulio Rastelli
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
hdac6 inhibition
zinc-binding-group
hdac inhibitors
drug design
Online Access:http://dx.doi.org/10.1080/14756366.2021.1981306

Internet

http://dx.doi.org/10.1080/14756366.2021.1981306

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