Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria‐Targeted Atovaquone

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria‐Targeted Atovaquone

Abstract Atovaquone, an FDA‐approved drug for malaria, is known to inhibit mitochondrial electron transport. A recently synthesized mitochondria‐targeted atovaquone increased mitochondrial accumulation and antitumor activity in vitro. Using an in situ vaccination approach, local injection of mitocho...

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Bibliographic Details
Main Authors: Mofei Huang, Donghai Xiong, Jing Pan, Qi Zhang, Yian Wang, Charles R. Myers, Bryon D. Johnson, Micael Hardy, Balaraman Kalyanaraman, Ming You
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Advanced Science
Subjects:
in situ vaccination
lung cancer
mitochondria‐targeted atovaquone
mitochondrial bioenergetics
tumor immune microenvironment
Online Access:https://doi.org/10.1002/advs.202101267

Internet

https://doi.org/10.1002/advs.202101267

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