Pharmacological Activation of cGAS for Cancer Immunotherapy

Pharmacological Activation of cGAS for Cancer Immunotherapy

When compartmentally mislocalized within cells, nucleic acids can be exceptionally immunostimulatory and can even trigger the immune-mediated elimination of cancer. Specifically, the accumulation of double-stranded DNA in the cytosol can efficiently promote antitumor immunity by activating the cGAMP...

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Bibliographic Details
Main Authors: Kyle M. Garland, Jonah C. Rosch, Carcia S. Carson, Lihong Wang-Bishop, Ann Hanna, Sema Sevimli, Casey Van Kaer, Justin M. Balko, Manuel Ascano, John T. Wilson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
cancer
cGAS/STING pathway
endosomal escape
immunotherapy
innate immune agonist
intratumoral
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.753472/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.753472/full

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