An unexpected aerobic oxidation of α-amino boronic acid part of Borteomib, leading to (thermal) decomposition of this very expensive anti-cancer API
This project was started when an unknown peak was being detected in the organic volatile impurity (OVI) analysis (using the head-space vapor sampling procedure) of bortezomib (BZB) active pharmaceutical ingredient (API), in pharmaceutical companies. During the OVI analysis of the API of BZB...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Growing Science
2022-01-01
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| Series: | Current Chemistry Letters |
| Online Access: | http://www.growingscience.com/ccl/Vol11/ccl_2021_44.pdf |