Emerging Mechanisms of Fluoroquinolone Resistance

Broad use of fluoroquinolones has been followed by emergence of resistance, which has been due mainly to chromosomal mutations in genes encoding the subunits of the drugs' target enzymes, DNA gyrase and topoisomerase IV, and in genes that affect the expression of diffusion channels in the outer...

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Bibliographic Details
Main Author: David C. Hooper
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2001-04-01
Series:Emerging Infectious Diseases
Subjects:
Online Access:https://wwwnc.cdc.gov/eid/article/7/2/70-0337_article