Inhibited KdpFABC transitions into an E1 off-cycle state

Inhibited KdpFABC transitions into an E1 off-cycle state

KdpFABC is a high-affinity prokaryotic K+ uptake system that forms a functional chimera between a channel-like subunit (KdpA) and a P-type ATPase (KdpB). At high K+ levels, KdpFABC needs to be inhibited to prevent excessive K+ accumulation to the point of toxicity. This is achieved by a phosphorylat...

Full description

Bibliographic Details
Main Authors: Jakob M Silberberg, Charlott Stock, Lisa Hielkema, Robin A Corey, Jan Rheinberger, Dorith Wunnicke, Victor RA Dubach, Phillip J Stansfeld, Inga Hänelt, Cristina Paulino
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
cryo-EM
P-type ATPase
membrane transport mechanism
protein regulation
potassium uptake
structure–function
Online Access:https://elifesciences.org/articles/80988

Internet

https://elifesciences.org/articles/80988

Similar Items