Alzheimer's Disease Associated Presenilin 1 Interacts with HC5 and ZETA, Subunits of the Catalytic 20S Proteasome

Alzheimer's Disease Associated Presenilin 1 Interacts with HC5 and ZETA, Subunits of the Catalytic 20S Proteasome

Proteolytic processing and degradation tightly regulate the amount of stable, functional presenilin 1 (PSEN1) in the cell. The ∼46-kDa PSEN1 holoprotein is cleaved into a ∼30-kDa N-terminal fragment (NTF) and a ∼20-kDa C-terminal fragment (CTF) by an unknown protease. The fragments are stabilized in...

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Bibliographic Details
Main Authors: Geert Van Gassen, Chris De Jonghe, Stefan Pype, Wim Van Criekinge, Ann Julliams, Inge Vanderhoeven, Sarah Woodrow, Rudi Beyaert, Danny Huylebroeck, Christine Van Broeckhoven
Format: Article
Language:English
Published: Elsevier 1999-10-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996199902656

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http://www.sciencedirect.com/science/article/pii/S0969996199902656

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