Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway.

Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway.

Human Cytomegalovirus (HCMV) encodes multiple microRNAs (miRNAs) whose functions are just beginning to be uncovered. Using in silico approaches, we identified the Toll-Like Receptor (TLR) innate immunity pathway as a possible target of HCMV miRNAs. Luciferase reporter assay screens further identifie...

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Bibliographic Details
Main Authors: Igor Landais, Chantel Pelton, Daniel Streblow, Victor DeFilippis, Shannon McWeeney, Jay A Nelson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004881

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https://doi.org/10.1371/journal.ppat.1004881

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