Perlecan domain 1 recombinant proteoglycan augments BMP-2 activity and osteogenesis

Perlecan domain 1 recombinant proteoglycan augments BMP-2 activity and osteogenesis

<p>Abstract</p> <p>Background</p> <p>Many growth factors, such as bone morphogenetic protein (BMP)-2, have been shown to interact with polymers of sulfated disacharrides known as heparan sulfate (HS) glycosaminoglycans (GAGs), which are found on matrix and cell-surface...

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Bibliographic Details
Main Authors: DeCarlo Arthur A, Belousova Maria, Ellis April L, Petersen Donald, Grenett Hernan, Hardigan Patrick, O’Grady Robert, Lord Megan, Whitelock John M
Format: Article
Language:English
Published: BMC 2012-09-01
Series:BMC Biotechnology
Subjects:
Osteogenesis
BMP-2
Heparan sulfate
Chondroitin sulfate
Proteoglycan
TCP
Bone graft
Implant
Osteoblast
Perlecan
Online Access:http://www.biomedcentral.com/1472-6750/12/60

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http://www.biomedcentral.com/1472-6750/12/60

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