<i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> Antigens Elicit a Strong IgG4 Response in Patients with Multiple Sclerosis and Exacerbate Experimental Autoimmune Encephalomyelitis

<i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> Antigens Elicit a Strong IgG4 Response in Patients with Multiple Sclerosis and Exacerbate Experimental Autoimmune Encephalomyelitis

Neuroinflammation can be triggered by microbial products disrupting immune regulation. In this study, we investigated the levels of IgG1, IgG2, IgG3, and IgG4 subclasses against the heat shock protein (HSP)70<sub>533–545</sub> peptide and lipopentapeptide (MAP_Lp5) derived from <i>...

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Bibliographic Details
Main Authors: Davide Cossu, Yuji Tomizawa, Kazumasa Yokoyama, Tamami Sakanishi, Eiichi Momotani, Leonardo A. Sechi, Nobutaka Hattori
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Life
Subjects:
mycobacteria
multiple sclerosis
IgG4
experimental autoimmune encephalomyelitis
heath shock protein 70
Online Access:https://www.mdpi.com/2075-1729/13/7/1437

Internet

https://www.mdpi.com/2075-1729/13/7/1437

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