Exosomes from N-Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non-N-Myc amplified cells: implications of intra-tumour heterogeneity

Exosomes from N-Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non-N-Myc amplified cells: implications of intra-tumour heterogeneity

Neuroblastoma accounts for 15% of childhood cancer mortality. Amplification of the oncogene N-Myc is a well-established poor prognostic marker for neuroblastoma. Whilst N-Myc amplification status strongly correlates with higher tumour aggression and resistance to treatment, the role of N-Myc in the...

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Bibliographic Details
Main Authors: Pamali Fonseka, Michael Liem, Cemil Ozcitti, Christopher G. Adda, Ching-Seng Ang, Suresh Mathivanan
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Journal of Extracellular Vesicles
Subjects:
neuroblastoma
exosomes
n-myc
intra-tumour heterogeneity
chemoresistance
Online Access:http://dx.doi.org/10.1080/20013078.2019.1597614

Internet

http://dx.doi.org/10.1080/20013078.2019.1597614

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