The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of Merlin

The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of Merlin

Circumferential actin belts underlying the adherens junctions of columnar epithelial cell monolayers control intercellular surface tension and cell shape to maintain tissue integrity. Yes-associated protein (YAP) and its paralog TAZ are proliferation-activating transcriptional coactivators that shut...

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Bibliographic Details
Main Authors: Kana T. Furukawa, Kazunari Yamashita, Natsuki Sakurai, Shigeo Ohno
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
epithelial cell
proliferation
circumferential actin belt
YAP
TAZ
Hippo
Merlin
nuclear export
mechanotransduction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717309981

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http://www.sciencedirect.com/science/article/pii/S2211124717309981

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