The AhR‐SRC axis as a therapeutic vulnerability in BRAFi‐resistant melanoma
Abstract The nongenetic mechanisms required to control tumor phenotypic plasticity and shape drug‐resistance remain unclear. We show here that the Aryl hydrocarbon Receptor (AhR) transcription factor directly regulates the gene expression program associated with the acquisition of resistance to BRAF...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Springer Nature
2022-12-01
|
Series: | EMBO Molecular Medicine |
Subjects: | |
Online Access: | https://doi.org/10.15252/emmm.202215677 |