Doublecortin mutation leads to persistent defects in the Golgi apparatus and mitochondria in adult hippocampal pyramidal cells

Doublecortin mutation leads to persistent defects in the Golgi apparatus and mitochondria in adult hippocampal pyramidal cells

Human doublecortin (DCX) mutations are associated with severe brain malformations leading to aberrant neuron positioning (heterotopia), intellectual disability and epilepsy. DCX is a microtubule-associated protein which plays a key role during neurodevelopment in neuronal migration and differentiati...

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Bibliographic Details
Main Authors: M.A. Stouffer, R. Khalaf-Nazzal, C. Cifuentes-Diaz, G. Albertini, E. Bandet, G. Grannec, V. Lavilla, J.-F. Deleuze, R. Olaso, M. Nosten-Bertrand, F. Francis
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Neurobiology of Disease
Subjects:
Cortical malformation
Neurodevelopmental disorder
Mouse knockout
hippocampus
Molecular and cellular analysis
Morphology
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122000948

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http://www.sciencedirect.com/science/article/pii/S0969996122000948

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