Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs

Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs

The cellular abundance of mature microRNAs (miRNAs) is dictated by the efficiency of nuclear processing of primary miRNA transcripts (pri-miRNAs) into pre-miRNA intermediates. The Microprocessor complex of Drosha and DGCR8 carries this out, but it has been unclear what controls Microprocessor’s diff...

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Bibliographic Details
Main Authors: Victoria A. Church, Sigal Pressman, Mamiko Isaji, Mary Truscott, Nihal Terzi Cizmecioglu, Stephen Buratowski, Maxim V. Frolov, Richard W. Carthew
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
Drosophila
microRNA
RNA polymerase II
DGCR8
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312718

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http://www.sciencedirect.com/science/article/pii/S2211124717312718

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