Pancreatic beta-cell specific BAG3 knockout results in chronic hyperinsulinemia inducing insulin resistance

Pancreatic beta-cell specific BAG3 knockout results in chronic hyperinsulinemia inducing insulin resistance

Background: Insulin, secreted from pancreatic islets of Langerhans, is of critical importance in regulating glucose homeostasis. Defective insulin secretion and/or the inability of tissues to respond to insulin results in insulin resistance and to several metabolic and organ alterations. We have pre...

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Bibliographic Details
Main Authors: Verena Damiani, Alessia Lamolinara, Ilaria Cicalini, Maria Concetta Cufaro, Francesco Del Pizzo, Federica Di Marco, Piero Del Boccio, Beatrice Dufrusine, Michael Hahne, Rossano Lattanzio, Damiana Pieragostino, Manuela Iezzi, Massimo Federici, Maria Caterina Turco, Arianna Maiorana, Carlo Dionisi-Vici, Vincenzo De Laurenzi
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Molecular Metabolism
Subjects:
Glucose homeostasis
BAG3
Primary hyperinsulinism
Insulin resistance
Chronic kidney disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823000868

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http://www.sciencedirect.com/science/article/pii/S2212877823000868

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