Anti-Browning Effect of 2-Mercaptobenzo[<i>d</i>]imidazole Analogs with Antioxidant Activity on Freshly-Cut Apple Slices and Their Highly Potent Tyrosinase Inhibitory Activity

Anti-Browning Effect of 2-Mercaptobenzo[<i>d</i>]imidazole Analogs with Antioxidant Activity on Freshly-Cut Apple Slices and Their Highly Potent Tyrosinase Inhibitory Activity

Ten 2-mercaptobenzimidazole (2-MBI) analogs were synthesized as potential tyrosinase inhibitors because mercapto-containing compounds can bind to copper ions at the active site of tyrosinase to inhibit enzyme activity. Nine 2-MBI analogs showed sub-micromolar IC<sub>50</sub> values for m...

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Bibliographic Details
Main Authors: Jieun Lee, Hye Soo Park, Hee Jin Jung, Yu Jung Park, Min Kyung Kang, Hye Jin Kim, Dahye Yoon, Sultan Ullah, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Antioxidants
Subjects:
browning
melanin
tyrosinase
antioxidant
2-mercaptobenzo[<i>d</i>]imidazole
docking simulation
Online Access:https://www.mdpi.com/2076-3921/12/10/1814

Internet

https://www.mdpi.com/2076-3921/12/10/1814

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