Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance

Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance

Abstract Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation modifications remain unknown. Chemoresistance remains a daunting challenge to successful treatment. We found that lysine butyrylation (Kbu) is specifical...

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Bibliographic Details
Main Authors: Yan He, Can-Can Zheng, Jing Yang, Shu-Jun Li, Tao-Yang Xu, Xian Wei, Wen-You Chen, Zhi-Li Jiang, Jiao-Jiao Xu, Guo-Geng Zhang, Chao Cheng, Kui-Sheng Chen, Xing-Yuan Shi, Da-Jiang Qin, Jin-Bao Liu, Bin Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00570-y

Internet

https://doi.org/10.1038/s41421-023-00570-y

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