Cost-effective, green HPLC determination of losartan, valsartan and their nitrosodiethylamine impurity: application to pharmaceutical dosage forms

Angiotensin-converting enzyme inhibitors are one of the most widely used anti-hypertensive drugs which are used to reduce hypertension. In 2018, the United States Food and Drug Administration together with the European Medicine Agency declared the presence of carcinogenic nitrosamine impurities such...

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Bibliographic Details
Main Authors: Soad S. Abd El-Hay, Magda Elhenawee, Khaled Maged, Adel Ehab Ibrahim
Format: Article
Language:English
Published: The Royal Society 2022-06-01
Series:Royal Society Open Science
Subjects:
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsos.220250