B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease.

B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease.

Langerhans cell histiocytosis (LCH) features inflammatory granuloma characterised by the presence of CD1a+ dendritic cells or 'LCH cells'. Badalian-Very et al. recently reported the presence of a canonical (V600E)B-RAF mutation in 57% of paraffin-embedded biopsies from LCH granuloma. Here...

Full description

Bibliographic Details
Main Authors: Takeshi Satoh, Alexander Smith, Aurelien Sarde, Hui-chun Lu, Syed Mian, Celine Trouillet, Ghulam Mufti, Jean-Francois Emile, Franca Fraternali, Jean Donadieu, Frederic Geissmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3323620?pdf=render

Internet

http://europepmc.org/articles/PMC3323620?pdf=render

Similar Items