A clinically relevant large‐scale biomanufacturing workflow to produce natural killer cells and natural killer cell‐derived extracellular vesicles for cancer immunotherapy

A clinically relevant large‐scale biomanufacturing workflow to produce natural killer cells and natural killer cell‐derived extracellular vesicles for cancer immunotherapy

Abstract Natural killer cell‐derived extracellular vesicles (NK‐EVs) have shown promising potential as biotherapeutics for cancer due to their unique attributes as cytotoxic nanovesicles against cancer cells and immune‐modulatory activity towards immune cells. However, a biomanufacturing workflow is...

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Bibliographic Details
Main Authors: Frederic St‐Denis‐Bissonnette, Sarah E. Cummings, Shirley Qiu, Andrew Stalker, Gauri Muradia, Jelica Mehic, Karan Mediratta, Shelby Kaczmarek, Dylan Burger, Seung‐Hwan Lee, Lisheng Wang, Jessie R. Lavoie
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Journal of Extracellular Vesicles
Subjects:
biomanufacturing workflow
cancer immunotherapy
clinical‐grade
extracellular vesicles (EVs)
natural killer (NK) cells
scalable production
Online Access:https://doi.org/10.1002/jev2.12387

Internet

https://doi.org/10.1002/jev2.12387

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