New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies
Numerous cancers express platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs). By directly stimulating tumour cells in an autocrine manner or by stimulating tumour stromal cells in a paracrine manner, the platelet-derived growth factor (PDGF)/platelet-derived growth factor receptor (P...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-05-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223002792 |
| _version_ | 1797857665922105344 |
|---|---|
| author | Pratibha Pandey Fahad Khan Tarun Kumar Upadhyay Moon Seungjoon Moon Nyeo Park Bonglee Kim |
| author_facet | Pratibha Pandey Fahad Khan Tarun Kumar Upadhyay Moon Seungjoon Moon Nyeo Park Bonglee Kim |
| author_sort | Pratibha Pandey |
| collection | DOAJ |
| description | Numerous cancers express platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs). By directly stimulating tumour cells in an autocrine manner or by stimulating tumour stromal cells in a paracrine manner, the platelet-derived growth factor (PDGF)/platelet-derived growth factor receptor (PDGFR) pathway is crucial in the growth and spread of several cancers. To combat hypoxia in the tumour microenvironment, it encourages angiogenesis. A growing body of experimental data shows that PDGFs target malignant cells, vascular cells, and stromal cells to modulate tumour growth, metastasis, and the tumour microenvironment. To combat medication resistance and enhance patient outcomes in cancers, targeting the PDGF/PDGFR pathway is a viable therapeutic approach. There have been reports of anomalies in the PDGF pathway, including the gain of function point mutations, activating chromosomal translocations, or overexpression or amplification of PDGF receptors (PDGFRs). As a result, it has been shown that targeting the PDGF/PDGFR signaling pathway is an effective method for treating cancer. As a result, this study will concentrate on the regulation of the PDGF/PDGFR signaling system, in particular the current methods and inhibitors used in cancer treatment, as well as the associated therapeutic advantages and side effects. |
| first_indexed | 2024-04-09T21:01:32Z |
| format | Article |
| id | doaj.art-19086b47dbe84516b57e61ca6c1d83df |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-09T21:01:32Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-19086b47dbe84516b57e61ca6c1d83df2023-03-29T09:23:00ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-05-01161114491New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategiesPratibha Pandey0Fahad Khan1Tarun Kumar Upadhyay2Moon Seungjoon3Moon Nyeo Park4Bonglee Kim5Department of Biotechnology, Noida Institute of Engineering and Technology, Greater Noida, UP, IndiaDepartment of Biotechnology, Noida Institute of Engineering and Technology, Greater Noida, UP, India; Corresponding author.Department of Biotechnology, Parul Institute of Applied Sciences and Centre of Research for Development, Parul University, Vadodara 391760, IndiaChansol Hospital of Korean Medicine, 290, Buheung-ro, Bupyeong-gu, Incheon 21390, Republic of Korea; Department of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, Republic of Korea; Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, Republic of Korea; Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea; Corresponding author at: Department of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, Republic of Korea.Numerous cancers express platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs). By directly stimulating tumour cells in an autocrine manner or by stimulating tumour stromal cells in a paracrine manner, the platelet-derived growth factor (PDGF)/platelet-derived growth factor receptor (PDGFR) pathway is crucial in the growth and spread of several cancers. To combat hypoxia in the tumour microenvironment, it encourages angiogenesis. A growing body of experimental data shows that PDGFs target malignant cells, vascular cells, and stromal cells to modulate tumour growth, metastasis, and the tumour microenvironment. To combat medication resistance and enhance patient outcomes in cancers, targeting the PDGF/PDGFR pathway is a viable therapeutic approach. There have been reports of anomalies in the PDGF pathway, including the gain of function point mutations, activating chromosomal translocations, or overexpression or amplification of PDGF receptors (PDGFRs). As a result, it has been shown that targeting the PDGF/PDGFR signaling pathway is an effective method for treating cancer. As a result, this study will concentrate on the regulation of the PDGF/PDGFR signaling system, in particular the current methods and inhibitors used in cancer treatment, as well as the associated therapeutic advantages and side effects.http://www.sciencedirect.com/science/article/pii/S0753332223002792PDGFPDGF receptorsCancerClinical trialsSignaling pathway |
| spellingShingle | Pratibha Pandey Fahad Khan Tarun Kumar Upadhyay Moon Seungjoon Moon Nyeo Park Bonglee Kim New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies Biomedicine & Pharmacotherapy PDGF PDGF receptors Cancer Clinical trials Signaling pathway |
| title | New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies |
| title_full | New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies |
| title_fullStr | New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies |
| title_full_unstemmed | New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies |
| title_short | New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies |
| title_sort | new insights about the pdgf pdgfr signaling pathway as a promising target to develop cancer therapeutic strategies |
| topic | PDGF PDGF receptors Cancer Clinical trials Signaling pathway |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223002792 |
| work_keys_str_mv | AT pratibhapandey newinsightsaboutthepdgfpdgfrsignalingpathwayasapromisingtargettodevelopcancertherapeuticstrategies AT fahadkhan newinsightsaboutthepdgfpdgfrsignalingpathwayasapromisingtargettodevelopcancertherapeuticstrategies AT tarunkumarupadhyay newinsightsaboutthepdgfpdgfrsignalingpathwayasapromisingtargettodevelopcancertherapeuticstrategies AT moonseungjoon newinsightsaboutthepdgfpdgfrsignalingpathwayasapromisingtargettodevelopcancertherapeuticstrategies AT moonnyeopark newinsightsaboutthepdgfpdgfrsignalingpathwayasapromisingtargettodevelopcancertherapeuticstrategies AT bongleekim newinsightsaboutthepdgfpdgfrsignalingpathwayasapromisingtargettodevelopcancertherapeuticstrategies |