Impaired aldehyde detoxification exacerbates motor deficits in an alpha‐synuclein mouse model of Parkinson's disease

Abstract Introduction The discovery of biogenic aldehydes in the postmortem parkinsonian brain and the ability of these aldehydes to modify and cross‐link proteins has called attention to their possible role in Parkinson's disease. For example, many in vitro studies have found that the aldehyde...

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Bibliographic Details
Main Authors: Paul Anthony Martinez, Vanessa Elia Martinez, Sheela Rani, Meredith Murrell, Martin Javors, Jonathan Gelfond, Jonathan Alan Doorn, Elizabeth Fernandez, Randy Strong
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Brain and Behavior
Subjects:
Online Access:https://doi.org/10.1002/brb3.3150